PXD051407-2

PXD051407 is an original dataset announced via ProteomeXchange.

Title	Targeted MS validation of huntingtin protein interaction signatures in Huntington's disease mouse models
Description	Huntington’s disease (HD) is a debilitating progressive neurodegenerative disorder that has profound effects on an individual’s cognitive, motor, and behavioral functions. HD is caused by mutation in the huntingtin (HTT) gene that results in CAG repeat expansion and production of an aggregation-prone polyglutamine-containing protein (mHTT). The expression of mHTT causes selective degeneration, mainly in the striatum and cortex brain regions. Yet, the molecular signatures that underlie their selective sensitization remain incompletely characterized.
HostingRepository	PanoramaPublic
AnnounceDate	2025-04-17
AnnouncementXML	Submission_2025-04-17_15:43:56.499.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Todd Greco
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-12 10:40:46	ID requested
1	2025-02-18 12:07:43	announced
⏵ 2	2025-04-17 15:43:57	announced	: Added PubMed Id

Justice JL, Greco TM, Hutton JE, Reed TJ, Mair ML, Botas J, Cristea IM, Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures. Mol Syst Biol, 21(5):492-522(2025) [pubmed]

submitter keyword: IP-MS, PRM, HTT, S-Trap

Ileana Cristea
contact affiliation	Princeton University
contact email	icristea@princeton.edu
lab head
Todd Greco
contact affiliation	Princeton University
contact email	tgreco@princeton.edu
dataset submitter

Panorama Public dataset URI