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PXD051407

PXD051407 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTargeted MS validation of huntingtin protein interaction signatures in Huntington's disease mouse models
DescriptionHuntington’s disease (HD) is a debilitating progressive neurodegenerative disorder that has profound effects on an individual’s cognitive, motor, and behavioral functions. HD is caused by mutation in the huntingtin (HTT) gene that results in CAG repeat expansion and production of an aggregation-prone polyglutamine-containing protein (mHTT). The expression of mHTT causes selective degeneration, mainly in the striatum and cortex brain regions. Yet, the molecular signatures that underlie their selective sensitization remain incompletely characterized.
HostingRepositoryPanoramaPublic
AnnounceDate2025-02-18
AnnouncementXMLSubmission_2025-02-18_12:07:42.621.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterTodd Greco
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-04-12 10:40:46ID requested
⏵ 12025-02-18 12:07:43announced
Publication List
no publication
Keyword List
submitter keyword: IP-MS, PRM, HTT, S-Trap
Contact List
Ileana Cristea
contact affiliationPrinceton University
contact emailicristea@princeton.edu
lab head
Todd Greco
contact affiliationPrinceton University
contact emailtgreco@princeton.edu
dataset submitter
Full Dataset Link List
Panorama Public dataset URI

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