PXD051387-1
PXD051387 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | FTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregulating ACSL4 and TFRC |
| Description | Older livers are more prone to hepatic ischaemia/reperfusion injury (HIRI), which severely limits their utilization in liver transplantation (LT); however, the potential mechanism remains unclear. Here, we demonstrated older livers exhibit a higher degree of ferroptosis during HIRI. Inhibiting ferroptosis significantly attenuated older HIRI. Mass spectrometry revealed fat mass and obesity-associated gene (FTO) was downregulated in older livers, especially during HIRI. Overexpressing FTO ameliorated older HIRI by inhibiting ferroptosis. Mechanistically, ACSL4 and TFRC, two key positive contributors of ferroptosis, were targets of FTO. The mitigating effect of FTO on older HIRI required the inhibition of Acsl4 and Tfrc mRNA stability in a m6A-dependent manner. Furthermore, we demonstrated nicotinamide mononucleotide (NMN) could upregulate FTO demethylase activity to suppress ferroptosis and attenuate older HIRI. Collectively, these findings revealed an FTO-ACSL4/TFRC regulatory pathway that contributes to the pathogenesis of older HIRI, providing insight into the clinical translation of strategies related to the demethylase activity of FTO in order to improve graft function after older donor LT. |
| HostingRepository | iProX |
| AnnounceDate | 2024-04-12 |
| AnnouncementXML | Submission_2024-04-12_02:05:31.102.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xijing Yan |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-04-12 02:05:06 | ID requested | |
| ⏵ 1 | 2024-04-12 02:05:31 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: FTO deficiency, older livers exacerbates ferroptosis |
Contact List
| Yang Yang | |
|---|---|
| contact affiliation | The Third Affiliated Hospital of Sun Yat-sen University |
| contact email | yysysu@163.com |
| lab head | |
| Xijing Yan | |
| contact affiliation | The Third Affiliated Hospital of Sun Yat-sen University |
| contact email | yanxj07@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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