PXD051359-1
PXD051359 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome |
| Description | The efficacy of immunotherapy against colorectal cancer (CRC) is impaired by insufficient immune cell recruitment into the tumor microenvironment. Our study shows that targeting circDNA2v, a circular RNA commonly overexpressed in CRC, can be exploited to elicit cytotoxic T-cell recruitment. CircDNA2v functions through binding to IGF2BP3, preventing its ubiquitination, and prolonging IGF2BP3 half-life, which in turn sustains the mRNA level of the protooncogene c-Myc. Targeting circDNA2v by gene silencing downregulates c-Myc to concordantly induce tumor cell senescence and the release of proinflammatory mediators. Production of CXCL10 and IL-9 by CRC cells is elicited through JAK-STAT1 signaling, in turn promoting the chemotactic and cytolytic activities of CD8+ T cells. Clinical evidence associates increased circDNA2v expression in CRC tissues with reduction in CD8+ T-cell infiltration and worse outcomes. The regulatory relationship between circDNA2v, cellular senescence and tumor infiltrating lymphocytes thus provides a rationale approach for improving immunotherapy in CRC. |
| HostingRepository | iProX |
| AnnounceDate | 2024-04-11 |
| AnnouncementXML | Submission_2024-04-11_01:42:27.351.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Shuang Wu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-04-11 01:41:58 | ID requested | |
| ⏵ 1 | 2024-04-11 01:42:27 | announced | |
| 2 | 2024-12-08 20:16:48 | announced | 2024-12-09: Update information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: circular RNA, circDNA2v, IGF2BP3, c-Myc, senescence, CXCL10, IL-9, CD8+T cells |
Contact List
| Hao Gu | |
|---|---|
| contact affiliation | Anhui Medical University |
| contact email | guhao@ahmu.edu.cn |
| lab head | |
| Shuang Wu | |
| contact affiliation | Anhui Medical University |
| contact email | wushuang1994326@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
to receive all new ProteomeXchange dataset release announcements!
