PXD051275-2

PXD051275 is an original dataset announced via ProteomeXchange.

Title	Selective Mitochondrial Respiratory Complex I Subunit Deficiency Causes Tumor Immunogenicity
Description	Targeting of specific metabolic pathways in tumor cells has the potential to sensitize them to immune-mediated attack. Previous studies had implicated mitochondria as a potential target for cancer therapies. We screen several complex I subunit deletions for their ability to induce an immune dependent anti-tumor response. Proteomic analysis of tumors lacking the complex I subunit NDUFS4 showed an increase in proteins involved in peptide antigen processing and presentation. We determined this increase in protein levels to be driven epigenetically through H3K27 acetylation from mitochondrial derived acetyl-CoA.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_07:00:46.488.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pere Puigserver
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-08 08:54:58	ID requested
1	2024-10-05 11:07:18	announced
⏵ 2	2024-10-22 07:00:46	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Mitochondria, Cancer, Immunology

Pere Puigserver
contact affiliation	Cancer Biology Department, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
contact email	pere.puigserver@dfci.harvard.edu
lab head
Pere Puigserver
contact affiliation	Dana-Farber Cancer Intitute, Harvard Medical School
contact email	pere_puigserver@dfci.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD051275

PRIDE project URI

• PRIDE
  1. PXD051275
     1. Label: PRIDE project
     2. Name: Selective Mitochondrial Respiratory Complex I Subunit Deficiency Causes Tumor Immunogenicity