PXD051233-1

PXD051233 is an original dataset announced via ProteomeXchange.

Title	External validation of serum biomarkers predicting short-term and mid/long-term relapse in Crohn’s disease patients stopping infliximab
Description	Background and aims: In Crohn’s disease (CD) patients on combination therapy (infliximab and immunosuppressant) and stopping infliximab (STORI cohort), the risk of short-term (<6 months) and mid/long-term relapse (>6 months) was associated with specific blood protein profiles. Our aim was to test the external validity of this finding in the SPARE cohort. Methods: The SPARE trial included patients with CD in sustained steroid-free clinical remission, on combination therapy and randomly allocated to one of three arms: continuing combination therapy, stopping infliximab or stopping immunosuppressant. As it was performed in STORI, 202 immune-related proteins were measured in the baseline serum of SPARE (arm stopping infliximab, n=63-67). The proteins associated with time to relapse (univariable Cox model) were compared between STORI and SPARE. The external validation of biomarkers (individually and combined by pairs) was evaluated by a discrimination analysis (c-statistic) and compared to CRP, faecal calprotectin and a previously validated model (CEASE). Results: In STORI and SPARE, specific blood protein profiles were associated with the risk of short-term (eg, high level: CRP, HP, IL6, CLEC4C, 3.5
HostingRepository	PanoramaPublic
AnnounceDate	2024-08-31
AnnouncementXML	Submission_2024-08-31_12:29:40.493.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Nicolas Pierre
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4); Label:13C(6)15N(1)
Instrument	Xevo TQ-S

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-06 09:39:16	ID requested
⏵ 1	2024-08-31 12:29:41	announced

Pierre N, Huynh-Thu VA, Baiwir D, Mazzucchelli G, Fl, é, ron M, Trzpiot L, Eppe G, De Pauw E, Laharie D, Satsangi J, Bossuyt P, Vuitton L, Vieujean S, Colombel JF, Meuwis MA, Louis E, Dupas JL, Laharie D, Reimund JM, Bouhnik Y, Jouet P, Vos M, Belaiche J, Louis E, Colombel JF, Vernier-Massouille G, Nancey S, Grimaud JC, Veyrac M, Boureille A, Flamant M, Jian R, Marteau P, Lemann M, Allez M, Savoye G, Duclos B, Picon L, Andrews A, Sparrow M, Leong R, Connor S, Radforth-Smith G, De Cruz P, Baert F, Louis E, Bossuyt P, Resche-Rignon M, Ding N, Almer S, Ben-Horin S, Colombel JF, Siegmund B, Preiss J, Stallmach A, Liceni T, Grip O, Halfvarson J, Durai D, Cummings F, Seilinger C, Parkes M, Lindsay J, Lambrecht G, Van Hootegem P, Rahier JF, Dewitte M, Hebuterne X, Chanteloup E, Altwegg R, Nancey S, Bouguen G, Pineton de Chambrun G, Pollenot F, Bouhnik Y, Vuitton L, Nachury M, Laharie D, Nancey S, Fumery M, Bouguen G, Picon L, Gilletta C, Viennot S, Roblin X, Satsangi J, Lindsay J, Parkes M, Irving P, Lamb C, Durai D, Pollok R, D'haens G, Hertervig E, Grip O, Halfvarsson J, External validation of serum biomarkers predicting short-term and mid/long-term relapse in patients with Crohn's disease stopping infliximab. Gut, 73(12):1965-1973(2024) [pubmed]

submitter keyword: Crohn’s disease, infliximab withdrawal, relapse prediction, biomarkers

Edouard Louis
contact affiliation	Laboratory of Translational Gastroenterology, GIGA-institute, University of Liege, Liege, Belgium
contact email	Edouard.Louis@uliege.be
lab head
Nicolas Pierre
contact affiliation	Laboratory of Translational Gastroenterology, GIGA-institute, University of Liege, Liege, Belgium
contact email	nicolas.pierre@uliege.be
dataset submitter

Panorama Public dataset URI