PXD051199-1
PXD051199 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Development of novel chemical inhibitors of SETD8 |
Description | SETD8 is a histone methyltransferase that catalyzes the monomethylation of histone H4K20. Overexpressed in cancer, several studies have suggested that it could be a potential target for treatment in certain tumors. However, there are currently very few SETD8 inhibitors, and all of them have bad pharmacological properties. Based on previously published structures of SETD8 bound to an H4K20me peptide, we have discovered a new chemical series of SETD8 inhibitors. As part of the characterization of these molecules, we conducted Thermal Proteome Profiling, aiming to discover potential additional targets as well as a better understanding of the signaling pathways that are affected by the drug. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-17 |
AnnouncementXML | Submission_2024-10-17_08:35:40.856.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Rozbeh Jafari |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-04-04 10:57:35 | ID requested | |
⏵ 1 | 2024-10-17 08:35:41 | announced |
Publication List
10.1038/s41419-024-07106-6; |
Murga M, Lopez-Pernas G, Soliva R, Fueyo-Marcos E, Amor C, Faustino I, Serna M, Serrano AG, D, í, az L, Mart, í, nez S, Blanco-Aparicio C, Ant, ó, n ME, Seashore-Ludlow B, Pastor J, Jafari R, Lafarga M, Llorca O, Orozco M, Fern, á, ndez-Capetillo O, SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis. Cell Death Dis, 15(9):694(2024) [pubmed] |
Keyword List
submitter keyword: drug targets, thermal proteoome profiling,Cancer |
Contact List
Rozbeh Jafari | |
---|---|
contact affiliation | Karolinska Institute, Department of Oncology-pathology |
contact email | rozbeh.jafari@ki.se |
lab head | |
Rozbeh Jafari | |
contact affiliation | Karolinska Institutet |
contact email | rozbeh.jafari@ki.se |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD051199 |
PRIDE project URI |
Repository Record List
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