PXD051188-1
PXD051188 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteome analysis of i-motif DNA binding proteins |
| Description | Non-canonical DNA structures such as G-quadruplex (G4) and i-motif (iM) are formed at the guanine- and cytosine-rich sequences, respectively, and prohibit DNA replication and transcription. The formation and resolution of these non-canonical structures are therefore required to be dynamically regulated by either physiological conditions or factors able to bind the G4 and iM structures. Although many G4 binding proteins responsible for tuning of the G4 structure have been discovered, understanding of structural regulation of the iM structure by iM binding proteins is far less behind. Here, we developed a protein-labeling DNA probe bearing an alkyne moiety through a reactive tosylate linker for proximity labeling of nucleic acid-binding proteins and searched for iM binding proteins. The proteome analyses of the captured proteins suggested new candidates that potentially bind the iM structure, in addition to the known iM binders. |
| HostingRepository | jPOST |
| AnnounceDate | 2024-10-15 |
| AnnouncementXML | Submission_2024-10-14_19:51:45.898.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Junpei Yamamoto |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxymethyl-L-cysteine; L-methionine sulfoxide |
| Instrument | instrument |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-04-04 00:45:54 | ID requested | |
| ⏵ 1 | 2024-10-14 19:51:46 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: non-canonical DNA structures, i-motif, proximity labeling |
Contact List
| Junpei Yamamoto | |
|---|---|
| lab head | |
| Junpei Yamamoto | |
| contact affiliation | Osaka University |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003020/ |
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