PXD051153-1

PXD051153 is an original dataset announced via ProteomeXchange.

Title	HDX-MS analysis of hPLCγ1 binding interactions with a small molecule compound
Description	We used HDX-MS to map potential binding sites of a small molecule compund on hPLCγ1. We identified multiple sites which show a conformational change upon ligand binding indicating this compund is able to interact with hPLCγ1.
HostingRepository	PRIDE
AnnounceDate	2025-10-15
AnnouncementXML	Submission_2025-10-15_14:12:54.528.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	John Burke
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	impact HD

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-02 09:52:34	ID requested
⏵ 1	2025-10-15 14:12:55	announced

Bunney TD, Nyvall HG, Macrae C, Lalovi, ć D, Gregory A, Le Huray KIP, Harvey N, Pinotsis N, Kalli AC, Waudby CA, Burke JE, Katan M, enzymes and implications for development of their specific inhibitors. Biochem J, 482(20):(2025) [pubmed]

10.1042/bcj20253358;

submitter keyword: HDX-MS, hPLCγ1

Dr. John E. Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
lab head
John Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD051153

PRIDE project URI

• PRIDE
  1. PXD051153
     1. Label: PRIDE project
     2. Name: HDX-MS analysis of hPLCγ1 binding interactions with a small molecule compound