PXD051149-1

PXD051149 is an original dataset announced via ProteomeXchange.

Title	ACKR3 conformational changes upon nanobody binding
Description	Here we used Hydrogen/Deuterium exchange mass spectrometry (HDX-MS) to examine the binding mode and mechanism of action of various nanobodies on ACKR3.
HostingRepository	PRIDE
AnnounceDate	2025-12-04
AnnouncementXML	Submission_2025-12-04_07:50:49.290.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Functional Proteomics Platform FPP
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	carbamoylated residue; monohydroxylated residue
Instrument	nanoACQUITY UPLC with HDX Technology; Synapt G2 HDMS

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-02 06:19:26	ID requested
⏵ 1	2025-12-04 07:50:49	announced

10.1038/S41467-025-65858-X;

submitter keyword: HDX-MS, Nb, GPCR

Chérine Bechara
contact affiliation	University of Montpellier, Institut de Génomique Fonctionnelle, France
contact email	Cherine.bechara@igf.cnrs.fr
lab head
Functional Proteomics Platform FPP
contact affiliation	FPP CNRS
contact email	contact@fpp.cnrs.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD051149

PRIDE project URI

• PRIDE
  1. PXD051149
     1. Label: PRIDE project
     2. Name: ACKR3 conformational changes upon nanobody binding