PXD051143-1

PXD051143 is an original dataset announced via ProteomeXchange.

Title	SOX11-SMARCA4 Complex Drives Oncogenic Gene Regulation in Mantle Cell Lymphoma
Description	SOX11 pioneer transcription factor is aberrantly expressed, it has an oncogenic role and its overexpression associates with worse prognosis in patients with mantle cell lymphomas (MCL). Using a proximity labeling (BioID2)/Mass Spectrometry-based proteomic strategyies, we identified SMARCA4, the central catalytic subunit of the SWI/SNF chromatin-remodeling complex, as one of the most significant SOX11-specific interacting proteins. SMARCA4 expression is directly regulated by SOX11, and its upregulation is associated with worse overall survival in patients with MCL, independently of other high-risk factors. Integration of global DNA-binding and transcriptomic profiles revealed that SOX11 and SMARCA4 share 60% specific peaks, predominantly in promoter regions. Disruption of SOX11:SMARCA4 interaction via SOX11 knockout or SMARCA4 PROTAC-degradation significantly reduced co-occupancy and co-targeted gene expression, including key BCR signaling pathway components. Our results suggest that SOX11:SMARCA4 complex binds to common regulatory sequences enabling the accession to chromatin and transcriptomic regulation of key oncogenic pathways for the development of MCL pathogenesis.
HostingRepository	PRIDE
AnnounceDate	2025-08-04
AnnouncementXML	Submission_2025-08-03_16:05:54.575.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Paula Carrillo Rodríguez
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-02 01:19:22	ID requested
⏵ 1	2025-08-03 16:05:55	announced

10.1038/s41408-025-01333-6;

De Bol, ò, s A, Carreras-Caball, é M, Sureda-G, ó, mez M, Rodr, í, guez ML, Charalampopoulou S, Albero R, Maiques-Diaz A, Playa-Albinyana H, Clot G, L, ó, pez C, Colomer D, Martin-Subero JI, Campo E, Reverter D, Villanueva J, Amador V, The SOX11:SMARCA4 complex is a driver of oncogenic transcriptional programs in mantle cell lymphoma. Blood Cancer J, 15(1):127(2025) [pubmed]

submitter keyword: SMARCA4, CUT&RUN-sequencing., SRY-related HMG-box 11 (SOX11),Mantle cell lymphoma, SWI/SNF chromatin remodeling complex, Pioneer Transcription Factor

Virginia Amador
contact affiliation	Centre Esther Koplowitz (CEK)
contact email	vamador@recerca.clinic.cat
lab head
Paula Carrillo Rodríguez
contact affiliation	Vall d'Hebron Institute of Oncolgoy
contact email	paulacrdgz@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD051143

PRIDE project URI

• PRIDE
  1. PXD051143
     1. Label: PRIDE project
     2. Name: SOX11-SMARCA4 Complex Drives Oncogenic Gene Regulation in Mantle Cell Lymphoma