PXD051094 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | SKBR3/HER2+ Breast Cancer Cellular Response to Lapatinib and Ipatasertib Kinase Inhibitors |
| Description | To explore the broader impact of kinase inhibitors on breast cancer cells, SKBR3/HER2+ cells were treated with two small molecule drugs, i.e., Lapatinib (10 uM) - a Tyr kinase inhibitor, and Ipatasertib (1 uM) - a Ser/Thr kinase inhibitor. Serum-starved cells (24 h) were exposed for 36 h to Lapatinib/EGF or a combination of Lapatinib/Ipatasertib/EGF. EGF - only stimulated cells were used as control. The EGF concentration was 10 nM throughout all experiments. Proteomic profiles of nuclear and cytoplasmic cell fractions of treated vs non-treated cells were generated by nano-LC-MS/MS using an Orbitrap QE instrument. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_06:56:12.427.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Iulia M. Lazar |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | acetylated residue; monohydroxylated residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-03-29 14:06:25 | ID requested | |
| 1 | 2024-08-23 05:46:22 | announced | |
| 2 | 2024-09-09 03:39:09 | announced | 2024-09-09: Updated project metadata. |
| ⏵ 3 | 2024-10-22 06:56:12 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
| submitter keyword: SKBR3, Ipatasertib, Lapatinib,Breast cancer, HER2+ |
Contact List
| Iulia Lazar |
|---|
| contact affiliation | Virginia Tech |
| contact email | malazar@vt.edu |
| lab head | |
| Iulia M. Lazar |
|---|
| contact affiliation | Virginia Tech |
| contact email | malazar@vt.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD051094 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD051094
- Label: PRIDE project
- Name: SKBR3/HER2+ Breast Cancer Cellular Response to Lapatinib and Ipatasertib Kinase Inhibitors
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