PXD051087 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Processing of microbial glycolipids in lysosome expands the repertoire of TLR2 agonists |
| Description | The goal is to demonstrate that a fraction of lysosomal proteins purified from THP1 cells contains lipolytic activities capable of digesting a cell envelope compound (a tetra-acylated PIM) to generate acyl-forms not produced by Mtb. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-09 |
| AnnouncementXML | Submission_2026-09-09_02:05:58.062.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Alexandre STELLA |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-03-29 05:44:31 | ID requested | |
| ⏵ 1 | 2026-09-09 02:05:59 | announced | |
Publication List
| 10.1016/j.jlr.2026.101098; |
| Belkai S, Carrat C, Layre E, Cala-De Paepe D, Vercellone A, Blanc L, Dessaux C, Chanchabi C, Stella A, Burlet-Schiltz O, Canaan S, Vergne I, Nigou J, Gilleron M, Reevaluation of mycobacterial phosphatidyl-myo-inositol mannosides (PIMs) as Toll-like receptor 2 (TLR2) agonists. J Lipid Res, 67(8):101098(2026) [pubmed] |
Keyword List
| submitter keyword: receptor, CD1b, mycobacterium, acylation,lysosome, lipase |
Contact List
| Odile Burlet-Schiltz |
|---|
| contact affiliation | Proteomics and Mass Spectrometry of Biomolecules, ProteoToul Research Proteomics Facility of Toulouse, ProteoToul Services Proteomics French Infrastructure, ProFI IPBS, CNRS, UMR 5089 205 route de Narbonne BP 64182 31077 Toulouse Cedex France |
| contact email | Odile.Schiltz@ipbs.fr |
| lab head | |
| Alexandre STELLA |
|---|
| contact affiliation | CNRS |
| contact email | alexandre.stella@ipbs.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD051087 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD051087
- Label: PRIDE project
- Name: Processing of microbial glycolipids in lysosome expands the repertoire of TLR2 agonists
