PXD051036-1

PXD051036 is an original dataset announced via ProteomeXchange.

Title	LC-MS/MS identified the TRIM16-binding proteins
Description	Vascular calcification (VC) is highly prevalent in patients with chronic kidney disease (CKD). To date, effective treatments for VC are still lacking since the underlying mechanisms remains elusive. RNA-sequencing analysis revealed that the E3 ubiquitin ligase Tripartite motif 16 (TRIM16) may be a key modulator of VC. However, it remains unclear whether TRIM16-mediated ubiquitination contributes to VC. In the present study, we used LC-MS/MS to identify the substrates of TRIM16.
HostingRepository	iProX
AnnounceDate	2024-03-27
AnnouncementXML	Submission_2025-11-18_00:20:12.849.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zirong Lan
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-27 20:23:59	ID requested
⏵ 1	2025-11-18 00:20:13	announced

Lan Z, Liang Q, Li L, Liu F, Chen A, Ye Y, Feng L, Zhang Z, Zhang X, Ou JS, Lu L, Yan J, TRIM16 Mediates K63-Linked Ubiquitination of DAB2 to Facilitate Vascular Calcification. Circ Res, 137(4):551-568(2025) [pubmed]

submitter keyword: TRIM16

Jianyun Yan
contact affiliation	Department of Cardiology, Laboratory of Heart Center, Heart Center, Zhujiang Hospital, Southern Medical University
contact email	yanjy790@smu.edu.cn
lab head
Zirong Lan
contact affiliation	Department of Cardiology, Laboratory of Heart Center, Heart Center, Zhujiang Hospital, Southern Medical University
contact email	2691063839@qq.com
dataset submitter

iProX dataset URI