PXD050915-1

PXD050915 is an original dataset announced via ProteomeXchange.

Title	Molecular mechanisms of target organ damage in youth with primary hypertension
Description	High blood pressure or Primary Hypertension is associated with target organ damage (TOD) in both adults and youth, where TOD predicts the adverse cardiovscular (CV) events. The design and methods of the SHIP AHOY (Study of High Blood Pressure in Pediatrics, Adult Hypertension Onset in Youth) project have been discussed elsewhere (Mendizabal B, et al., 2018, Hypertension. 2018 Sep;72(3):625-631.). Briefly, SHIP AHOY study participants with normal (Cut off: SBP <80th%), and high- systolic blood pressure (Cut off: SBP >90th%), were stratified as with or without TOD, like Low LVMI (Left ventricular mass index) (Cut off: <38.6 gm/m2.7), and High LVMI (Cut off: >38.6 gm/m2.7), were selected in the present study cohort. Blood samples (for PBNCs and serum) were collected to investigate genetic, epigenetic, and proteomics changes that influence the development of hypertensive TOD in youth. We excluded youth with symptomatic severe hypertension, on antihypertensive or lipid-lowering medication in the past 6 months, with diabetes mellitus (type 1 or 2), kidney disease, or other chronic medical conditions. All study participants and their parents provided written informed consent and assent according to local investigational review board requirements. The mechanisms involved in blood pressure mediated TOD are limitedly understood in onset of TOD. To understand this, using RNA sequencing, we first identified candidate differentially expressed genes in circulating PBMCs of study participants. Next, through miRNA and whole genome bisulphite sequencing of circulating PBMCs we determined the epigenetic regulators of TOD. Also, using LCMS, serum proteomics, the key circulatory protein involved in advancing CV- TOD events was identified. In conclusion, multiomics approach was utilized to define the circulatory regulators involved in BP mediated CV-TOD.
HostingRepository	PRIDE
AnnounceDate	2025-12-15
AnnouncementXML	Submission_2025-12-14_18:06:12.489.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qin Fu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-22 16:11:22	ID requested
⏵ 1	2025-12-14 18:06:13	announced

Ananthamohan K, Brady TM, Arif M, Daniels SR, Falkner B, Ferguson M, Flynn JT, Hanevold C, Hooper SR, Ingelfinger JR, Lande M, Martin LJ, Meyers KE, Mitsnefes M, Rosner B, Samuels JA, Kuffel G, Zilliox MJ, Chen QM, Becker RC, Urbina EM, Sadayappan S, A Multiomics Approach to Defining Target-Organ Injury in Youths With Primary Hypertension: The SHIP AHOY Cohort. J Am Heart Assoc, 14(21):e037649(2025) [pubmed]

10.1161/jaha.124.037649;

submitter keyword: Adolescents

Angiogenesis

Hypertension

Target organ damage

Vasohibin-1

Qin Fu
contact affiliation	Cornell University
contact email	qf44@cornell.edu
lab head
Qin Fu
contact affiliation	Cornell University
contact email	qf44@cornell.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD050915

PRIDE project URI

• PRIDE
  1. PXD050915
     1. Label: PRIDE project
     2. Name: Molecular mechanisms of target organ damage in youth with primary hypertension