PXD050906-2

PXD050906 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Systematic profiling of lysine lactylation proteome reveals distinct changes in lactylation between the parental AGS cells and cisplatin-resistant AGS cells
Description	Lactate enable to cause a novel post-translational modification, lactylation of proteins. We are interested in exploring whether lactate modulates DNA-damaging agents resistance in the form of lactylation. To gain a global view of DNA-damaging agents resistance-related lactylation, especially Kla of nonhistone substrates, we used 4D-Label free high-resolution LC-MS/MS, quantitative lysine lactylation analysis to investigate Kla substrates in cisplatin-resistant AGS cells.
HostingRepository	PRIDE
AnnounceDate	2024-08-09
AnnouncementXML	Submission_2024-08-09_02:33:39.321.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hengxing Chen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-22 09:57:13	ID requested
1	2024-05-09 00:49:27	announced
⏵ 2	2024-08-09 02:33:40	announced	2024-08-09: Updated project metadata.
3	2024-10-22 06:38:41	announced	2024-10-22: Updated project metadata.

Publication List

10.1038/s41586-024-07620-9;
Chen H, Li Y, Li H, Chen X, Fu H, Mao D, Chen W, Lan L, Wang C, Hu K, Li J, Zhu C, Evans I, Cheung E, Lu D, He Y, Behrens A, Yin D, Zhang C, NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance. Nature, 631(8021):663-669(2024) [pubmed]

10.1038/s41586-024-07620-9;

Chen H, Li Y, Li H, Chen X, Fu H, Mao D, Chen W, Lan L, Wang C, Hu K, Li J, Zhu C, Evans I, Cheung E, Lu D, He Y, Behrens A, Yin D, Zhang C, NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance. Nature, 631(8021):663-669(2024) [pubmed]

Keyword List

submitter keyword: Lysine lactylation

submitter keyword: Lysine lactylation

Contact List

Hengxing Chen
contact affiliation	Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People’s Republic of China.
contact email	chenhx49@mail2.sysu.edu.cn
lab head
Hengxing Chen
contact affiliation	Sun Yat-sen University
contact email	chenhx49@mail2.sysu.edu.cn
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD050906
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD050906

PRIDE project URI

Repository Record List

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