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PXD050906-2

PXD050906 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSystematic profiling of lysine lactylation proteome reveals distinct changes in lactylation between the parental AGS cells and cisplatin-resistant AGS cells
DescriptionLactate enable to cause a novel post-translational modification, lactylation of proteins. We are interested in exploring whether lactate modulates DNA-damaging agents resistance in the form of lactylation. To gain a global view of DNA-damaging agents resistance-related lactylation, especially Kla of nonhistone substrates, we used 4D-Label free high-resolution LC-MS/MS, quantitative lysine lactylation analysis to investigate Kla substrates in cisplatin-resistant AGS cells.
HostingRepositoryPRIDE
AnnounceDate2024-08-09
AnnouncementXMLSubmission_2024-08-09_02:33:39.321.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHengxing Chen
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-03-22 09:57:13ID requested
12024-05-09 00:49:27announced
22024-08-09 02:33:40announced2024-08-09: Updated project metadata.
32024-10-22 06:38:41announced2024-10-22: Updated project metadata.
Publication List
10.1038/s41586-024-07620-9;
Chen H, Li Y, Li H, Chen X, Fu H, Mao D, Chen W, Lan L, Wang C, Hu K, Li J, Zhu C, Evans I, Cheung E, Lu D, He Y, Behrens A, Yin D, Zhang C, NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance. Nature, 631(8021):663-669(2024) [pubmed]
Keyword List
submitter keyword: Lysine lactylation
Contact List
Hengxing Chen
contact affiliationGuangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People’s Republic of China.
contact emailchenhx49@mail2.sysu.edu.cn
lab head
Hengxing Chen
contact affiliationSun Yat-sen University
contact emailchenhx49@mail2.sysu.edu.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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