PXD050859 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TMTpro-SP3-LC-MS analysis of peritoneal dialysis effluent of a phase 2 randomized clinical trial |
| Description | Peritoneal dialysis (PD) is a modality of renal replacement therapy in which the high volumes of available PD effluent (PDE) represents a rich source of biomarkers for monitoring disease and therapy. Although this information could help guiding the management of PD patients, little is known about the potential of PDE to define pathomechanism-associated molecular signatures in PD. Here we use a high-performance multiplex proteomics approach based on depletion of highly abundant plasma proteins and enrichment of low abundance proteins for PDE samples from PD patients of a phase 2 randomized clinical trial, who received either standard PD fluid or a novel PD fluid (added alanyl-glutamine (AlaGln)) in an open-label, randomized, single-center, cross-over clinical trial. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-27 |
| AnnouncementXML | Submission_2026-04-26_19:20:34.272.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Klaus Kratochwill |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-03-21 07:01:59 | ID requested | |
| ⏵ 1 | 2026-04-26 19:20:35 | announced | |
Publication List
| 10.1016/j.ekir.2026.106342; |
| Herzog R, Daniel-Fischer L, Eibensteiner F, Sobieszek IJ, Unterwurzacher M, Sacnun JM, Uhl PKT, Lang E, Wagner A, K, รถ, nig F, Alper SL, Davies LC, Aufricht C, Vychytil A, Kratochwill K, Local Immunometabolic Intervention With Alanyl-Glutamine Resolves Peritoneal Dialysis-Induced Immune Cell Dysfunction. Kidney Int Rep, 11(5):106342(2026) [pubmed] |
Keyword List
| submitter keyword: TMT,peritoneal dialysis |
Contact List
| Dr Klaus Kratochwill |
|---|
| contact affiliation | Medical University of Vienna |
| contact email | klaus.kratochwill@meduniwien.ac.at |
| lab head | |
| Klaus Kratochwill |
|---|
| contact affiliation | Medical University of Vienna |
| contact email | klaus.kratochwill@meduniwien.ac.at |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD050859
- Label: PRIDE project
- Name: TMTpro-SP3-LC-MS analysis of peritoneal dialysis effluent of a phase 2 randomized clinical trial
