PXD050765 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of acute pancreatitis in TRP14-KO miceProteomic analysis of acute pancreatitis in TRP14-KO mice |
Description | We have studied pancreas samples in pancreas from a mouse model of acute pancreatitis, comparing wild-type animals and TRP14 KO animals. Samples are extracted with N-ethylmaleimide to block reduced cysteines, and no reducing agent is used, with a search including cysteinylated peptides. Acute pancreatitis was induced in 12 weeks-old mice (wild-type and KO for TRP14) by seven intraperitoneal injections of cerulein (50 µg/kg body weight) at 1 h intervals. Then, 1 h after the last injection, animals were euthanized under anesthesia with 3% isoflurane, exsanguinated, and the pancreas was immediately removed and processed. |
HostingRepository | PRIDE |
AnnounceDate | 2024-05-15 |
AnnouncementXML | Submission_2024-05-15_10:02:17.183.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD050765 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Antonio Martínez Ruiz |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | cysteinylation (disulfide with free L-cysteine); N-ethylmaleimide derivatized cysteine; monohydroxylated residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-03-19 06:21:13 | ID requested | |
⏵ 1 | 2024-05-15 10:02:17 | announced | |
Publication List
Keyword List
submitter keyword: mouse model, cysteine, disulfide exchange,Pancreatitis, biological redox systems, oxidative stress |
Contact List
Antonio Martínez-Ruiz |
contact affiliation | Unidad de Investigación, Hospital Santa Cristina, Instituto de Investigación Sanitaria Princesa (IIS-IP), Madrid, Spain |
contact email | amartinezruiz@salud.madrid.org |
lab head | |
Antonio Martínez Ruiz |
contact affiliation | Instituto de Investigacion Sanitaria Princesa (IIS-IP) |
contact email | amartinezruiz@salud.madrid.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD050765
- Label: PRIDE project
- Name: Proteomic analysis of acute pancreatitis in TRP14-KO miceProteomic analysis of acute pancreatitis in TRP14-KO mice