PXD050653-1

PXD050653 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of mouse liver lesions at all three stages of Echinococcus granulosus infection
Description	Infection with Echinococcus granulosus, a life-threatening zoonotic parasite, can remain asymptomatic for a long time; it is generally detectable only in the advanced stages, which delays treatment in most patients. Here, we aimed to determine what E. granulosus infection does to the host organs and how E. granulosus evades the host immune system and remains undetectable for a long time, and eventually understand the interactions between E. granulosus and the hosts in depth. Therefore, we established a mouse model of E. granulosus infection at the early, middle, and late stages, obtained samples from its liver (the most frequently affected host organ), and performed comparative, quantitative proteomic analyses. Our results indicated the potential changes in the host lesion proteome during the development of E. granulosus infection. They may aid in developing methods for early and effective diagnosis of cystic echinococcosis and identifying relevant core regulatory targets of parasite–host interactions.
HostingRepository	PRIDE
AnnounceDate	2024-11-07
AnnouncementXML	Submission_2024-11-06_17:05:58.129.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nan Jiang
SpeciesList	scientific name: Echinococcus granulosus; NCBI TaxID: 6210;
ModificationList	No PTMs are included in the dataset
Instrument	Thermo Fisher Scientific instrument model

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-15 05:07:39	ID requested
⏵ 1	2024-11-06 17:05:58	announced

Dataset with its publication pending

submitter keyword: Echinococcus granulosus；infection；parasite-host interaction；proteomics；hepatic lesions

Jianping Cao
contact affiliation	1 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Center for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai 200025, China 2 The School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
contact email	caojp@chinacdc.cn
lab head
Nan Jiang
contact affiliation	National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention
contact email	drjiangn0712@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/11/PXD050653

PRIDE project URI

• PRIDE
  1. PXD050653
     1. Label: PRIDE project
     2. Name: Proteomic analysis of mouse liver lesions at all three stages of Echinococcus granulosus infection