PXD050633-1

PXD050633 is an original dataset announced via ProteomeXchange.

Title	HDX-MS analysis of PI4Ka trimer and FAM126a (415-521) with calcineurin
Description	We used HDX-MS to map novel binding sites of calcineurin on PI4KA and FAM126A. Calcineurin binds to PxIxIT and LxVP motifs on PI4KA and FAM126A indicating a novel regulatory mechanism of Pi4KA by calcineurin
HostingRepository	PRIDE
AnnounceDate	2024-09-03
AnnouncementXML	Submission_2024-09-03_13:29:29.180.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	John Burke
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	impact HD

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-14 17:57:05	ID requested
⏵ 1	2024-09-03 13:31:34	announced

Shaw AL, Suresh S, Parson MAH, Harris NJ, Jenkins ML, Yip CK, Burke JE, Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A. Structure, 32(11):1973-1983.e6(2024) [pubmed]

10.1016/j.str.2024.08.007;

submitter keyword: HDX-MS, PI4Ka, FAM126a, calcineurin

Dr. John E. Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
lab head
John Burke
contact affiliation	University of Victoria
contact email	jeburke@uvic.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD050633

PRIDE project URI

• PRIDE
  1. PXD050633
     1. Label: PRIDE project
     2. Name: HDX-MS analysis of PI4Ka trimer and FAM126a (415-521) with calcineurin