PXD050610 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The Human Cardiac “Age-OME”: Age-specific changes in myocardial molecular |
| Description | Ageing is one of the most significant risk factors for heart disease, however, it is still not clear how the human heart changes with age. Taking advantage of a unique set of pre-mortem, cryopreserved, non-diseased human hearts, we performed omics analyses (transcriptomics, proteomics, metabolomics, and lipidomics), coupled with biologically-informed computational modelling in younger (≤25 years old) and older hearts (≥50 years old) to describe the molecular landscape of human cardiac ageing. In older hearts, we observed a downregulation of proteins involved in calcium signalling and contractile apparatus. Furthermore, we found a potential dysregulation of central carbon generation of fuel, glycolysis and fatty acids oxidation, along with an increase in long-chain fatty acids. This study presents and analyses the first molecular data set of normal human cardiac ageing, which has relevant implications for understanding the human cardiac ageing process and the development of age-related heart disease. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-17 |
| AnnouncementXML | Submission_2025-11-16_18:04:42.133.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Mark Larance |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-03-14 01:14:43 | ID requested | |
| ⏵ 1 | 2025-11-16 18:04:46 | announced | |
Publication List
| 10.1111/acel.70219; |
| Malecki C, Guglielmi G, Hunter B, Harney D, Koay YC, Don AS, Han O, Khor J, Nguyen L, Pan M, Gawthrop P, Isles N, Chung J, Hume RD, Taper M, Wang X, Larance M, Spill F, Rajagopal V, O'Sullivan JF, Lal S, The Human Cardiac "Age-OME": Age-Specific Changes in Myocardial Molecular Expression. Aging Cell, 24(11):e70219(2025) [pubmed] |
Keyword List
| submitter keyword: Human, metabolism, heart, aging, Excitation-Contraction Coupling |
Contact List
| Mark Larance |
|---|
| contact affiliation | School of Medical Sciences, Faculty of Medicine and Healthy, University of Sydney, Sydney, Australia. |
| contact email | mark.larance@sydney.edu.au |
| lab head | |
| Mark Larance |
|---|
| contact affiliation | The University of Sydney |
| contact email | mark.larance@sydney.edu.au |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD050610 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD050610
- Label: PRIDE project
- Name: The Human Cardiac “Age-OME”: Age-specific changes in myocardial molecular
