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PXD050597-1

PXD050597 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDental calculus formation rate: the role of salivary proteome and metaproteome
DescriptionThis study investigated the differences in saliva composition between individuals with rapid and slow dental calculus formation rates. A total of 26 patients were evaluated for their salivary electrochemical properties, and proteomic, metaproteomic, and elemental compositions. After dental cleaning and a six-month reassessment, patients were categorized into slow (57.7%) and rapid (42.3%) calculus formers. Results indicated that rapid formers had a more neutral zeta-potential, lower salivary calcium ion concentration, distinct protein profiles including 38 exclusive proteins, and pathways related to cell binding, inflammatory mediation, and neurodegenerative disorders. In contrast, slow formers showed an immune response enrichment and a different bacterial composition, with a predominance of Streptococci in rapid formers and Rothia in slow formers. The study concludes that rapid calculus formers' saliva significantly differs in several key compositions from slow formers.
HostingRepositoryPRIDE
AnnounceDate2024-09-04
AnnouncementXMLSubmission_2024-09-04_05:35:46.609.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterWenji Cai
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetic acid derivatized residue; deamidated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-03-13 12:59:19ID requested
12024-09-04 05:35:46announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: dental calculus, proteomics, salivary proteome, metaproteome, human saliva, zeta potential
Contact List
Faleh Tamimi
contact affiliationMcGill University-Faculty of Dentistry 3640 University Street, Room M64, Montreal, QC Canada, H3A 0C7
contact emailfaleh.tamimimarino@mcgill.ca
lab head
Wenji Cai
contact affiliationMcGill University
contact emailwenji.cai@mail.mcgill.ca
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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