PXD050571-1

PXD050571 is an original dataset announced via ProteomeXchange.

Title	DDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding
Description	Hyaline cartilage fibrosis is one of the important reasons for the poor prognosis of advanced osteoarthritis (OA), and is the main factor leading to joint stiffness and deformity. However, the mechanism of hyaline cartilage fibrosis remains largely unclear. Here we found that DDX5, one of the founding members of the DEAD-box RNA helicase family, was dramatically downregulated in the degenerated articular cartilage of aged mice, destabilization of the medial meniscus murine model as well as patients with OA. Our data suggest that strategies aimed at upregulation of DDX5 will be of great value for the treatment of cartilage fibrosis and damage in OA.
HostingRepository	iProX
AnnounceDate	2024-03-13
AnnouncementXML	Submission_2024-03-12_22:08:30.000.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Linhui Zhai
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-12 22:06:50	ID requested
⏵ 1	2024-03-12 22:08:30	announced
2	2024-10-17 20:25:30	announced	2024-10-18: Update information.

Dataset with its publication pending

submitter keyword: DDX5, COL2, COL1, alternative splicing, G-quadruplex, osteoarthritis

Minjia Tan
contact affiliation	Shanghai Institute of Materia Medica
contact email	mjtan@simm.ac.cn
lab head
Linhui Zhai
contact affiliation	Shanghai Institute of Materia Medica
contact email	zhailinhui@163.com
dataset submitter

iProX dataset URI