PXD050569-1

PXD050569 is an original dataset announced via ProteomeXchange.

Title	Mass-spectroscopic quantification of CHAC1-regulated protein cysteine S-glutathionylation
Description	S-glutathionylation is an important post-translational modification of a cysteine residue of target protein. We applied a quantitative redox proteomics approach to identify the specific cysteine residues as targets of S-glutathionylation. Using this approach, we profiled CHAC1-associated changes in glutathionylome in APAP-induced hepatoxicity and ferroptosis. Primary mouse hepatocytes (PMHs) were infected with Ad-GFP or Ad-CHAC1 for 36 h, and then challenged with 20 mM APAP for 3 h followed by the enrichment and quantitative analysis of glutathionylated proteins.
HostingRepository	iProX
AnnounceDate	2024-03-12
AnnouncementXML	Submission_2025-03-31_19:43:14.379.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaobo Li
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-12 22:00:30	ID requested
⏵ 1	2025-03-31 19:43:14	announced
2	2025-08-28 23:57:05	announced	2025-08-29: Add info.

Dataset with its publication pending

submitter keyword: S-glutathionylation

CHAC1

ferroptosis

acetaminophen

hepatocytes

Xiaobo Li
contact affiliation	Fudan University
contact email	xbli@fudan.edu.cn
lab head
Xiaobo Li
contact affiliation	Fudan University
contact email	xbli@fudan.edu.cn
dataset submitter

iProX dataset URI