PXD050563-1

PXD050563 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Degron-based targeted protein degradation systems in mice
Description	To investigate the specificity of protein degradation and identify potential neo-substrates for the OsTIR1-AID2 and hCRBN-S4D systems, we conducted proteomics analyses of thymocytes 16 hours after intraperitoneal injection of 5-Ph-IAA or PBS in Rosa26OsTIR1/+;Satb1V-AID/V-AID and Rosa26OsTIR1/+;Satb1 +/+ mice, as well as POM or DMSO in Rosa26hCRBN/+;Satb1V-S4D/V-S4D and Rosa26hCRBN/+;Satb1+/+ mice, alongside with wildtype control mice. Furthermore, we conducted proteomics analysis in the cerebrum of DMSO- and POM-treated Rosa26hCRBN/+;Satb1+/+ mice to identify neo-substrates in the brain for the hCRBN-S4D system.
HostingRepository	jPOST
AnnounceDate	2024-10-25
AnnouncementXML	Submission_2024-10-24_08:00:12.646.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Koshi Imami
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	S-carboxamidomethyl-L-cysteine; unknown modification
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-12 19:11:29	ID requested
⏵ 1	2024-10-24 08:00:13	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: degron, AID2, CRBN

submitter keyword: degron, AID2, CRBN

Contact List

Ichiro Taniuchi
lab head
Koshi Imami
contact affiliation	RIKEN
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002981/