PXD050563-1
PXD050563 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Degron-based targeted protein degradation systems in mice |
Description | To investigate the specificity of protein degradation and identify potential neo-substrates for the OsTIR1-AID2 and hCRBN-S4D systems, we conducted proteomics analyses of thymocytes 16 hours after intraperitoneal injection of 5-Ph-IAA or PBS in Rosa26OsTIR1/+;Satb1V-AID/V-AID and Rosa26OsTIR1/+;Satb1 +/+ mice, as well as POM or DMSO in Rosa26hCRBN/+;Satb1V-S4D/V-S4D and Rosa26hCRBN/+;Satb1+/+ mice, alongside with wildtype control mice. Furthermore, we conducted proteomics analysis in the cerebrum of DMSO- and POM-treated Rosa26hCRBN/+;Satb1+/+ mice to identify neo-substrates in the brain for the hCRBN-S4D system. |
HostingRepository | jPOST |
AnnounceDate | 2024-10-25 |
AnnouncementXML | Submission_2024-10-24_08:00:12.646.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Koshi Imami |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | S-carboxamidomethyl-L-cysteine; unknown modification |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-03-12 19:11:29 | ID requested | |
⏵ 1 | 2024-10-24 08:00:13 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: degron, AID2, CRBN |
Contact List
Ichiro Taniuchi | |
---|---|
lab head | |
Koshi Imami | |
contact affiliation | RIKEN |
dataset submitter |
Full Dataset Link List
jPOST dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST002981/ |