PXD050479-1

PXD050479 is an original dataset announced via ProteomeXchange.

Title	Characterisation of Platelet Releasate Proteome in Relapsing-Remitting Multiple Sclerosis Reveals Dysregulation of Inflammatory Signalling and Extracellular Vesicle Dynamics
Description	Multiple Sclerosis is an inflammatory neurodegenerative disease characterised by blood-brain barrier dysfunction and leukocyte infiltration into the central nervous system. Platelets are best known for their contributions to haemostasis, however upon activation platelets release an abundance of soluble and vesicular-associated proteins, termed the platelet releasate (PR). This milieu contains numerous inflammatory and vasoactive proteins which function to attract leukocytes and alter endothelial permeability. Here, we aimed to characterise the PR of Relapsing-Remitting multiple sclerosis (RRMS) patients, previously characterized with respect to thrombin generation dynamics compared to healthy controls. We carried out LFQ proteomic profiling of the PR from 15 RRMS and 19 aged-matched healthy controls. The PR proteome identified 9 proteins increased and 16 proteins decreased in RRMS patients.
HostingRepository	PRIDE
AnnounceDate	2025-01-09
AnnouncementXML	Submission_2025-01-09_08:21:19.759.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martin Kenny
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-08 04:33:41	ID requested
⏵ 1	2025-01-09 08:21:20	announced

10.1002/PRCA.202400019;

submitter keyword: multiple sclerosis,Platelet releasate

Patricia B. Maguire
contact affiliation	SPHERE research group, Conway Institute, University College Dublin, Dublin, Ireland
contact email	patricia.maguire@ucd.ie
lab head
Martin Kenny
contact affiliation	SPHERE research group, Conway Institute, University College Dublin, Dublin, Ireland. School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland.
contact email	martin.kenny@ucd.ie
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD050479
     1. Label: PRIDE project
     2. Name: Characterisation of Platelet Releasate Proteome in Relapsing-Remitting Multiple Sclerosis Reveals Dysregulation of Inflammatory Signalling and Extracellular Vesicle Dynamics