PXD050470-1

PXD050470 is an original dataset announced via ProteomeXchange.

Title	Global profiling of protein lactylation in Human hippocampi
Description	Lysine lactylation (Kla) is a novel posttranslational modification, playing important roles in numerous biological processes, including transcription, metabolism, tumorigenesis and nervous system diseases. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), researchers have identified lactylation in many human organs and other species, but no research on lactylation in human hippocampi has been reported. In this study, we performed global profiling of lactylation in human hippocampi under normal physiological conditions, and we identified 2579 Class I (localization probabilities > 0.75) lactylated sites in 853 proteins. Bioinformatics analysis showed that lactylated proteins were mainly located in the cytoplasm and involved in metabolic pathways and some neurological diseases. Compared with those reported lactylation databases, 434 lactylated proteins were identified for the first time in this study. Our work expands the database on human lactylation and helps advance the study on lactylation function and regulation under physiological and pathological conditions.
HostingRepository	iProX
AnnounceDate	2024-03-08
AnnouncementXML	Submission_2025-01-06_18:47:49.184.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chunmei Shi
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	lactic acid
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-07 20:00:43	ID requested
⏵ 1	2025-01-06 18:47:50	announced

Shi CM, Wang QC, Li XL, Yang YH, Tang XY, Wu Y, Ding T, Zhang XT, Zhang ZY, Han R, Kong J, Liu JF, Yang JT, Global Profiling of Protein Lactylation in Human Hippocampi. Proteomics Clin Appl, ():e202400061(2024) [pubmed]

submitter keyword: human hippocampus, lactylation, LC-MS/MS, posttranslational modification

Juntao Yang
contact affiliation	Peking Union Medical College
contact email	superyjt79@163.com
lab head
Chunmei Shi
contact affiliation	Peking Union Medical College
contact email	shicm0304@163.com
dataset submitter

iProX dataset URI