PXD050455-1

PXD050455 is an original dataset announced via ProteomeXchange.

Title	Identification of BBOX1 binding partners using AP-MS in ccRCC tumors
Description	Gamma-Butyrobetaine Hydroxylase 1 (BBOX1) is a 2-OG dependent enzyme evolving in carnitine synthesis and lipid metabolism. In this study, we propose BBOX1 is a potential tumor suppressor in kidney cancer. We found that BBOX1 is generally underexpressed in ccRCC cells and patients. Restore BBOX1 in ccRCC cells suppresses tumor growth in multiple xenograft mouse models. To understand the potential mechanism, we plan to perform IP-Mass spec analysis in the cell-derived xenograft tumors with or without BBOX1 expression to identify novel binding partners which mediate the tumor suppressive role of BBOX1 in ccRCC.
HostingRepository	PRIDE
AnnounceDate	2024-12-23
AnnouncementXML	Submission_2024-12-23_10:25:07.699.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chengheng liao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-07 10:15:02	ID requested
⏵ 1	2024-12-23 10:25:08	announced

Dataset with its publication pending

submitter keyword: BBOX1, ccRCC

Qing Zhang
contact affiliation	UT Southwestern Medical Center
contact email	Qing.Zhang@utsouthwestern.edu
lab head
Chengheng liao
contact affiliation	UT Southwestern Medical Center
contact email	liaochengheng@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/12/PXD050455

PRIDE project URI

• PRIDE
  1. PXD050455
     1. Label: PRIDE project
     2. Name: Identification of BBOX1 binding partners using AP-MS in ccRCC tumors