PXD050420-1

PXD050420 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	EGFR-TKI-down-regulated proteins in HCC827 cells
Description	EGFR mediates stabilities of a wide spectrum of proteins. Treatment of the cells with EGFR tyrosine kinase inhibitors (EGFR-TKIs) leads to degradation of these proteins. To define the proteins and corresponding pathways of EGFR-stabilized proteins, we use mass spectrum to quantify the protein levels in the untreated control HCC827 cells and the cells treated with erlotinib or gefitinib.
HostingRepository	PRIDE
AnnounceDate	2025-05-13
AnnouncementXML	Submission_2025-05-13_06:03:50.415.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD050420
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Li Zheng
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-06 15:34:02	ID requested
⏵ 1	2025-05-13 06:03:51	announced

Publication List

10.6019/PXD050420;
Wang Y, Fernandez A, Pei X, Liu B, Shen L, Yan Y, Solanki HS, Yang L, Zhou M, Guo Y, Wu J, Reckamp KL, Zheng L, Shen B, EGFR-mediated HSP70 phosphorylation facilitates PCNA association with chromatin and DNA replication. Nucleic Acids Res, 52(21):13057-13072(2024) [pubmed]
10.1093/nar/gkae938;

10.6019/PXD050420;

Wang Y, Fernandez A, Pei X, Liu B, Shen L, Yan Y, Solanki HS, Yang L, Zhou M, Guo Y, Wu J, Reckamp KL, Zheng L, Shen B, EGFR-mediated HSP70 phosphorylation facilitates PCNA association with chromatin and DNA replication. Nucleic Acids Res, 52(21):13057-13072(2024) [pubmed]

10.1093/nar/gkae938;

Keyword List

submitter keyword: Human EGFR mutated lung cancer cells

submitter keyword: Human EGFR mutated lung cancer cells

Contact List

Binghui Shen
contact affiliation	City of Hope Beckman Research Institute
contact email	bshen@coh.org
lab head
Li Zheng
contact affiliation	City of Hope Beckman Research Institute
contact email	lzheng@coh.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD050420
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD050420

PRIDE project URI

Repository Record List

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