PXD050415 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Unraveling the Molecular Landscape of Lead-Induced Cochlear Synaptopathy: A Quantitative Proteomic Analysis |
Description | This study investigates how lead exposure triggers cochlear synaptopathy and hearing loss in mice. Young-adult CBA/J mice were given lead acetate in drinking water for 28 days. We assessed hearing thresholds, outer hair cell activity, and synaptic changes in the cochlea. Lead exposure raises hearing thresholds, indicating cochlear synaptopathy. Notably affects synapses in the basal turn without impacting outer hair cells. In addition to this, lead altered the abundance of 352 synaptic proteins, with the synaptic vesicle cycle pathway prominently affected. Lead-induced cochlear synaptopathy targets basal cochlear regions, implicating synaptic vesicle cycle signaling in hearing loss. Revealing specific mechanisms behind lead-induced hearing deficits enhances targeted interventions and preventive strategies, advancing our understanding of lead induced hearing loss. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-17 |
AnnouncementXML | Submission_2024-10-17_05:30:23.265.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Pankaj Bhatia |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Eclipse |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-03-06 12:29:27 | ID requested | |
⏵ 1 | 2024-10-17 05:30:24 | announced | |
Publication List
Bhatia P, Mehmood S, Doyon-Reale N, Rosati R, Stemmer PM, Jamesdaniel S, Unraveling the molecular landscape of lead-induced cochlear synaptopathy: a quantitative proteomics analysis. Front Cell Neurosci, 18():1408208(2024) [pubmed] |
10.3389/fncel.2024.1408208; |
Keyword List
submitter keyword: Pb,Mouse, hearing loss, cochlea, LC-MS/MS |
Contact List
Samson Jamesdaniel, PhD |
contact affiliation | Institute of Environmental Health Sciences Wayne State University Detroit, MI USA 46202 |
contact email | fn2963@wayne.edu |
lab head | |
Pankaj Bhatia |
contact affiliation | Wayne State University |
contact email | pankaj.bhatia@wayne.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD050415 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD050415
- Label: PRIDE project
- Name: Unraveling the Molecular Landscape of Lead-Induced Cochlear Synaptopathy: A Quantitative Proteomic Analysis