PXD050415-1

PXD050415 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Unraveling the Molecular Landscape of Lead-Induced Cochlear Synaptopathy: A Quantitative Proteomic Analysis
Description	This study investigates how lead exposure triggers cochlear synaptopathy and hearing loss in mice. Young-adult CBA/J mice were given lead acetate in drinking water for 28 days. We assessed hearing thresholds, outer hair cell activity, and synaptic changes in the cochlea. Lead exposure raises hearing thresholds, indicating cochlear synaptopathy. Notably affects synapses in the basal turn without impacting outer hair cells. In addition to this, lead altered the abundance of 352 synaptic proteins, with the synaptic vesicle cycle pathway prominently affected. Lead-induced cochlear synaptopathy targets basal cochlear regions, implicating synaptic vesicle cycle signaling in hearing loss. Revealing specific mechanisms behind lead-induced hearing deficits enhances targeted interventions and preventive strategies, advancing our understanding of lead induced hearing loss.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_05:30:23.265.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pankaj Bhatia
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-06 12:29:27	ID requested
⏵ 1	2024-10-17 05:30:24	announced

Publication List

Bhatia P, Mehmood S, Doyon-Reale N, Rosati R, Stemmer PM, Jamesdaniel S, Unraveling the molecular landscape of lead-induced cochlear synaptopathy: a quantitative proteomics analysis. Front Cell Neurosci, 18():1408208(2024) [pubmed]
10.3389/fncel.2024.1408208;

Bhatia P, Mehmood S, Doyon-Reale N, Rosati R, Stemmer PM, Jamesdaniel S, Unraveling the molecular landscape of lead-induced cochlear synaptopathy: a quantitative proteomics analysis. Front Cell Neurosci, 18():1408208(2024) [pubmed]

10.3389/fncel.2024.1408208;

Keyword List

submitter keyword: Pb,Mouse, hearing loss, cochlea, LC-MS/MS

submitter keyword: Pb,Mouse, hearing loss, cochlea, LC-MS/MS

Contact List

Samson Jamesdaniel, PhD
contact affiliation	Institute of Environmental Health Sciences Wayne State University Detroit, MI USA 46202
contact email	fn2963@wayne.edu
lab head
Pankaj Bhatia
contact affiliation	Wayne State University
contact email	pankaj.bhatia@wayne.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD050415
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD050415

PRIDE project URI

Repository Record List

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