PXD050397 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studies |
Description | The consequences at the molecular level and the mechanisms involved in a possible cardioprotective effect of antihypertensive treatment are not yet fully understood. Here, the efficacy of pyridostigmine (PYR) and trandolapril (TRA) as antihypertensive and antihypertrophic agents was investigated and compared in hypertensive SHR and normotensive WKY rats. In parallel, we investigated the effects of these drugs on myocardial β-adrenergic and cholinergic signaling pathways and protein expression profiles. |
HostingRepository | PRIDE |
AnnounceDate | 2024-09-10 |
AnnouncementXML | Submission_2024-09-10_07:24:55.481.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Pavel Talacko |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-03-06 03:08:21 | ID requested | |
⏵ 1 | 2024-09-10 07:24:55 | announced | |
2 | 2024-10-22 06:57:56 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: cholinergic signaling, pyridostigmine, trandolapril,acetylcholinesterase, hypertension, myocardial proteome, SHR and WKY rats |
Contact List
Jiri Novotny |
contact affiliation | Department of Physiology, Faculty of Science, Charles University, 128 00 Prague, Czechia |
contact email | jiri.novotny@natur.cuni.cz |
lab head | |
Pavel Talacko |
contact affiliation | BIOCEV, Faculty of Science, Charles University in Prague |
contact email | pavel.talacko@natur.cuni.cz |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD050397
- Label: PRIDE project
- Name: Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studies