PXD050397-1

PXD050397 is an original dataset announced via ProteomeXchange.

Title	Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studies
Description	The consequences at the molecular level and the mechanisms involved in a possible cardioprotective effect of antihypertensive treatment are not yet fully understood. Here, the efficacy of pyridostigmine (PYR) and trandolapril (TRA) as antihypertensive and antihypertrophic agents was investigated and compared in hypertensive SHR and normotensive WKY rats. In parallel, we investigated the effects of these drugs on myocardial β-adrenergic and cholinergic signaling pathways and protein expression profiles.
HostingRepository	PRIDE
AnnounceDate	2024-09-10
AnnouncementXML	Submission_2024-09-10_07:24:55.481.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pavel Talacko
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-06 03:08:21	ID requested
⏵ 1	2024-09-10 07:24:55	announced
2	2024-10-22 06:57:56	announced	2024-10-22: Updated project metadata.

10.3389/FCVM.2024.1390547;

submitter keyword: cholinergic signaling, pyridostigmine, trandolapril,acetylcholinesterase, hypertension, myocardial proteome, SHR and WKY rats

Jiri Novotny
contact affiliation	Department of Physiology, Faculty of Science, Charles University, 128 00 Prague, Czechia
contact email	jiri.novotny@natur.cuni.cz
lab head
Pavel Talacko
contact affiliation	BIOCEV, Faculty of Science, Charles University in Prague
contact email	pavel.talacko@natur.cuni.cz
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD050397
     1. Label: PRIDE project
     2. Name: Modulation of left ventricular hypertrophy in spontaneously hypertensive rats by acetylcholinesterase and ACE inhibitors: physiological, biochemical, and proteomic studies