PXD050360-1

PXD050360 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of vascular tissue from critical limb ischemia mouse models treated with Etrinabdione
Description	Vasculogenic therapies have been investigated for the treatment of peripheral artery disease (PAD) with very limited success in clinical trials. The isoform PP2A (protein phosphatase 2)/B55alpha inhibits the activity of the prolyl hydroxylase 2 (PHD2) and activates the hypoxia inducing factor-1alpha (HIF-1alpha), playing a key role in in vessel remodeling. Thus, PP2A/B55alpha activators may have the potential to induce angiogenesis and arteriogenesis. Herein we investigated the pharmacological attributes of VCE-004.8 (Etrinabdione) and its effectiveness in a murine model of critical limb ischemia.
HostingRepository	PRIDE
AnnounceDate	2024-04-03
AnnouncementXML	Submission_2024-04-03_01:29:10.180.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martin Garrido
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Bruker Daltonics timsTOF series

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-05 06:18:48	ID requested
⏵ 1	2024-04-03 01:29:10	announced

Dataset with its publication pending

submitter keyword: Vascular tissue, critical limb ischemia

Eduardo Muñoz
contact affiliation	Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Córdoba, Spain Cellular Biology, Physiology and Immunology Department, University of Córdoba, Spain Hospital Universitario Reina Sofía, Córdoba, Spain
contact email	fi1muble@uco.es
lab head
Martin Garrido
contact affiliation	Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany
contact email	martin.garrido@uni-heidelberg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD050360

PRIDE project URI

• PRIDE
  1. PXD050360
     1. Label: PRIDE project
     2. Name: Proteomic analysis of vascular tissue from critical limb ischemia mouse models treated with Etrinabdione