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PXD050265-1

PXD050265 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGlobal population analysis of HLA class I affinity toward proteasome-generated peptides from five main SARS-CoV-2 spike protein RBD variants
DescriptionHere we report binding index of 305 human HLA class I molecules from 18,771 unique haplotypes of 28,104 individuals to the 821 peptides experimentally observed from spike protein receptor-binding domain (RBD) of 5 main SARS-CoV-2 strains hydrolysed by human proteasomes with constitutive and immuno catalytic phenotypes. Our data read that 4 point mutations in the C-terminal RBD region 496-505 of Omicron B1.1.529 strain results in a dramatic increase of proteasome-mediated release of two public HLA class I epitopes covering 82% and 27% of world population haplotypes. Global population analysis of HLA class I haplotypes specific to these peptides demonstrated decreased mortality of human populations bearing these haplotypes to COVID-19 after but not before December, 2021, when Omicron spread over the world and became dominant SARS-CoV-2 strain. Analysis of population frequency of HLA class I alleles revealed that HLA-B*07:02, -B*08:01, -B*15:01, -C*01:02, -C*06:02 and -C*07:02 potentially provides increased resistance of human population to Omicron. Concluding, we found direct experimental observation, which might be one of the key factors that forced the SARS-CoV-2 virus to cross back the red line of pandemic status.
HostingRepositoryPRIDE
AnnounceDate2025-01-29
AnnouncementXMLSubmission_2025-01-29_07:39:25.463.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterIvan Butenko
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Severe acute respiratory syndrome coronavirus 2; NCBI TaxID: 2697049;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-03-01 03:11:40ID requested
12025-01-29 07:39:25announced
Publication List
10.1016/J.ISCI.2025.111873;
Keyword List
submitter keyword: SARS-CoV-2
proteasome
immunoproteasome
HLA class I
IFNγ
Contact List
Dr. Belogurov
contact affiliationShemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russian Federation Scientific Research Instirute for Systems Biology and Medicine, Moscow, Russian Federation
contact emailalexey.belogurov.jr@gmail.com
lab head
Ivan Butenko
contact affiliationScientific Research Institute for Systems Biology and Medicine, Moscow, Russian Federation
contact emailivan.butenko@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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