PXD050263-1

PXD050263 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Deficiency in the SNARE protein SYNTAXIN-11 causes a secondary B cell defect
Description	CD4 T cell help requires functional SNARE protein SYNTAXIN-11 for successful interaction with B cells, CD40L mobilization and secretion of IL-2 and IL-10 to promote B cell differentiation, germinal centre formation and class switch. STX11-deficieny results in hypogammaglobulinemia suggesting a higher risk for infections.
HostingRepository	MassIVE
AnnounceDate	2024-04-26
AnnouncementXML	Submission_2024-04-26_01:52:22.381.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Stefan Tholen
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-01 02:36:47	ID requested
⏵ 1	2024-04-26 01:52:22	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: STX11, SNARE protein, B cells, humoral immunity, hypogammaglobulinemia, mouse model

submitter keyword: STX11, SNARE protein, B cells, humoral immunity, hypogammaglobulinemia, mouse model

Contact List

Dr. Sandra Ammann
contact affiliation	Institute for Immunodeficiency; Medical Center, University of Freiburg
contact email	sandra.ammann@uniklinik-freiburg.de
lab head
Stefan Tholen
contact affiliation	Uniklinik Freiburg
contact email	stefan.tholen@uniklinik-freiburg.de
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000094210/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000094210/