PXD050234-1

PXD050234 is an original dataset announced via ProteomeXchange.

Title	Proteomic landscapes of Ewing sarcoma unravel immunological regulation of tumor progression
Description	To gain a comprehensive molecular and functional view of the tumors in their microenvironment, we performed a deep mass spectrometry-based proteomic analysis of 168 tumors from 72 patients from primary, relapsed, and metastatic tumors. Analysis of more than 10,000 proteins across patients revealed novel insights into cancer prognosis, chemo-resistance, and progression. We found ferroptosis inhibition as a potential mediator of EWS chemo-resistance and identified novel subclasses of EWS that link the tumor immune landscape with DNA damage repair, ubiquitin-related proteins, and patient prognosis. Validation by multiplexed immunofluorescence imaging confirmed a significant association between patient prognosis and tumor neutrophils, suggesting potential neutrophil-targeted strategies for future treatment
HostingRepository	PRIDE
AnnounceDate	2026-01-01
AnnouncementXML	Submission_2026-01-01_05:30:46.409.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tamar Geiger
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-28 23:36:26	ID requested
⏵ 1	2026-01-01 05:30:46	announced

Dataset with its publication pending

submitter keyword: MS-based proteomics, Neutrophils, Therapy,Ewing Sarcoma, Pediatric cancers, Ferroptosis, Immune

Prof. Tamar Geiger
contact affiliation	Cancer proteomics lab Department of Molecular Cell Biology Weizmann Institute of Science
contact email	tami.geiger@weizmann.ac.il
lab head
Tamar Geiger
contact affiliation	Weizmann Institute of Science
contact email	geiger@tauex.tau.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD050234

PRIDE project URI

• PRIDE
  1. PXD050234
     1. Label: PRIDE project
     2. Name: Proteomic landscapes of Ewing sarcoma unravel immunological regulation of tumor progression