PXD050113-1

PXD050113 is an original dataset announced via ProteomeXchange.

Title	Epi-proteomic assessment of backpain therapy
Description	This study investigates how molecular profiles evolve in response to standardized sport therapy and non-controlled lifestyle choices. We report that the therapy improves agility, attenuates backpain, and also triggers healthier habits. We find that a subset of participants´ histone methylation and acetylation profiles cluster samples according to their therapy status, before or after therapy. Integrating epigenetic reprogramming of both buccal cells and PBMCs reveals that these concomitant changes are concordant with higher levels of self-rated backpain improvement and agility gain. Additionally, epigenetic changes correlate with changes in immune-response plasma factors, reflecting their comparable ability to rate therapy effects at the molecular level. Additionally, we performed an exploratory analysis to confirm the usability of molecular profiles in 1) mapping lifestyle choices, and 2) evaluating the distance of a given participant to an optimal health state.
HostingRepository	PRIDE
AnnounceDate	2024-10-21
AnnouncementXML	Submission_2024-10-21_02:09:07.095.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Moritz Voelker-Albert
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monomethylated residue; acetylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-25 01:10:59	ID requested
⏵ 1	2024-10-21 02:09:07	announced

10.3389/FSPOR.2024.1393067;

submitter keyword: PBMC,Histone PTMs, Buccal Swabs, Proteome, Backpain therapy

Dr. Moritz Voelker-Albert
contact affiliation	General Manager MOLEQLAR Analytics GmbH
contact email	moritz@moleqlar.de
lab head
Moritz Voelker-Albert
contact affiliation	MOLEQLAR Analytics GmbH
contact email	moritz@moleqlar.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD050113
     1. Label: PRIDE project
     2. Name: Epi-proteomic assessment of backpain therapy