PXD050102-1

PXD050102 is an original dataset announced via ProteomeXchange.

Title	Dyrk1a P21 phosphoprotoemic data
Description	Dyrk1A deficiency is linked to various neurodevelopmental disorders, including developmental delays and autism spectrum disorders (ASD). Haploinsufficiency of Dyrk1a in mice leads to ASD-related phenotypes, although key pathological mechanisms remain unclear. In addition, human DYRK1A mutations have not been characterized in mice. Here we report Dyrk1a-knockin mice carrying a human mutation (Ile48LysfsX2; Dyrk1a-I48K mice). These mice display severe microcephaly, social and cognitive deficits, dendritic shrinkage, excitatory synaptic deficits, and altered phospho-proteome patterns enriched for multiple signaling pathways and synaptic proteins. Early chronic lithium treatment of newborn mutant mice rescues brain volume, behavior, dendrite, synapse, and signaling/synapse phospho-proteome phenotypes at juvenile and adult stages. These results suggest that signaling/synaptic alterations contribute to phenotypic alterations in Dyrk1a-I48K mice, and that early correction of these alterations by lithium treatment has long-lasting effects of preventing juvenile and adult-stage phenotypes.
HostingRepository	PRIDE
AnnounceDate	2024-12-04
AnnouncementXML	Submission_2024-12-04_02:19:35.067.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yeji Yang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-24 00:10:19	ID requested
⏵ 1	2024-12-04 02:19:35	announced

Dataset with its publication pending

submitter keyword: Dyrk1a,ASD, phosphorylation, LC-MS/MS

Eunjoon Kim
contact affiliation	2Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST)
contact email	kime@kaist.ac.kr
lab head
Yeji Yang
contact affiliation	Korea Basic Science Institute
contact email	yangyj@kbsi.re.kr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD050102
     1. Label: PRIDE project
     2. Name: Dyrk1a P21 phosphoprotoemic data