PXD050010 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma |
Description | Multiple myeloma is an incurable hematological malignancy evolving from precursor states to advanced phases of the disease. MYC abnormalities play a critical role in the disease progression. Nevertheless, MYC lacks therapeutic drugability, thereby necessitating the exploration of alternative strategies aimed at circumventing the challenges associated with targeting MYC. In this study, we hypothesized that MYC upregulation induces genomic dependencies in tumor cells, creating vulnerabilities that can be exploited therapeutically. We discovered a differential dependency on glutamine metabolism in MYC overexpressing cells. We functionally explored these dependencies as a selective targetable vulnerability in vitro and in vivo. Furthermore, we uncovered a potential synergistic combination that can exacerbated this metabolic vulnerability, Collectively, our in vitro and in vivo results revealed an effective therapeutic combinatory strategy in the context of MYC overexpressing MM. |
HostingRepository | PRIDE |
AnnounceDate | 2024-04-09 |
AnnouncementXML | Submission_2024-04-09_05:17:01.191.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Lama Hasan Bou Issa |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-02-21 09:47:02 | ID requested | |
⏵ 1 | 2024-04-09 05:17:02 | announced | |
Publication List
Hasan Bou Issa L, Fl, é, chon L, Laine W, Ouelkdite A, Gaggero S, Cozzani A, Tilmont R, Chauvet P, Gower N, Sklavenitis-Pistofidis R, Brinster C, Thuru X, Touil Y, Quesnel B, Mitra S, Ghobrial IM, Kluza J, Manier S, MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma. iScience, 27(4):109417(2024) [pubmed] |
10.1016/j.isci.2024.109417; |
Keyword List
submitter keyword: TMT spectrometry,MYC, U266, GLS1, NAMPT, gene dependency, MYC overexpression, cellular metabolism, multiple myeloma |
Contact List
Salomon Manier |
contact affiliation | 1Canther, INSERM UMR-S1277 and CNRS UMR9020, Lille University, Lille 59000, France 2Department of Hematology, CHU Lille |
contact email | salomon.manier@inserm.fr |
lab head | |
Lama Hasan Bou Issa |
contact affiliation | Canther, INSERM UMR-S1277 and CNRS UMR9020, Lille University |
contact email | lama.hasan-bou-issa@inserm.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD050010
- Label: PRIDE project
- Name: MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma