PXD050002-1

PXD050002 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Role of complement system pathways in protective immune response to treatment with heat-inactivated Mycobacterium bovis
Description	Development of vaccines to preserve and improve human and animal health require effective protective antigens, delivery platforms and adjuvants. The immunostimulant adjuvant based on heat-inactivated Mycobacterium bovis (IV) was developed to boost protective immune response in different animal species against pathogen infection and tick infestations. To advance in vaccinology, in this study we used a serum proteomics approach with functional annotations and enrichment network analysis for the characterization of immune pathways and biomarkers associated with IV treatment in the wild boar animal model. The results support a role for IV in the activation of innate and adaptive immune responses through activation of humoral immune response, regulation of actin cytoskeleton pathway, coagulation cascade, complement system and innate immunity. A balance between different complement system pathways in response to IV activated antimicrobial responses while reducing risks for inflammatory diseases and pathogen-associated immunothrombosis. These results support a role for IV in stimulating protective immune and anti-inflammatory responses with application if different vaccine formulations.
HostingRepository	PRIDE
AnnounceDate	2025-10-15
AnnouncementXML	Submission_2025-10-15_05:38:13.369.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD050002
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Margarita Villar
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: NEWT:9913;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-21 07:17:58	ID requested
⏵ 1	2025-10-15 05:38:13	announced

Publication List

10.3389/FVETS.2025.1702063;
10.6019/PXD050002;

10.3389/FVETS.2025.1702063;

10.6019/PXD050002;

Keyword List

submitter keyword: Complement
Immunology
Proteomic
Tuberculosis
Vaccine
Wild boar

submitter keyword: Complement

Immunology

Proteomic

Tuberculosis

Vaccine

Wild boar

Contact List

Margarita Villar
contact affiliation	SaBio. Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, Ronda de Toledo s/n, 13005 Ciudad Real, Spain.
contact email	margaritam.villar@uclm.es
lab head
Margarita Villar
contact affiliation	University of Castilla- La Mancha
contact email	margaritam.villar@uclm.es
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD050002
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD050002

PRIDE project URI

Repository Record List

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