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PXD049987-1

PXD049987 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIntrauterine hyperglycemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling
DescriptionShort-term intrauterine hyperglycaemia significantly reduced lean mass in male offspring at 8 weeks, resulting in decreased exercise endurance and metabolic disorders. Disrupted organization and function of the mitochondria in skeletal muscle were also observed among them. Foetal exposure to hyperglycaemia decreased phosphorylated CREB and reduced the transcription of Ppargc1a.
HostingRepositoryPRIDE
AnnounceDate2024-08-09
AnnouncementXMLSubmission_2024-08-09_05:07:24.839.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYi-Shang Yan
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-02-21 06:52:32ID requested
12024-08-09 05:07:25announced
Publication List
Yan YS, Mo JY, Huang YT, Zhu H, Wu HY, Lin ZL, Liu R, Liu XQ, Lv PP, Feng C, Sheng JZ, Jin M, Huang HF, Intrauterine hyperglycaemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling. Nutr Diabetes, 14(1):56(2024) [pubmed]
10.1038/s41387-024-00299-x;
Keyword List
submitter keyword: mouse embryonic skeletal muscle in limb
Contact List
Yi-Shang Yan
contact affiliationThe second affiliated hospital, school of medicine, Zhejiang University, Hangzhou, China;
contact emailyanyishang@zju.edu.cn
lab head
Yi-Shang Yan
contact affiliationSecond Affiliated Hospital of Zhejiang University
contact emailyanyishang@zju.edu.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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