PXD049439 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Fkbp5 Gene Deletion: Impacts on Circadian Rhythmicity and Brain Proteomics in Aged Mice |
Description | FKBP51, also known as FK506-binding protein 51, is a molecular chaperone and scaffolding protein with significant roles in regulating hormone signaling and stress responding. Genetic variants in FKBP5, which encodes FKBP51, have been implicated in a growing number of neuropsychiatric disorders, which has spurred efforts to target FKBP51 therapeutically. However, the molecular mechanisms by which FKBP51 influences the pathways affected in these disorders are not fully understood. Protein changes in Fkbp5 KO mice, as measured by histology and proteomics, revealed alterations in a brain region- and sex-dependent manner. |
HostingRepository | PRIDE |
AnnounceDate | 2024-09-05 |
AnnouncementXML | Submission_2024-09-05_13:18:02.781.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Stanley Stevens |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-02-17 02:12:07 | ID requested | |
⏵ 1 | 2024-09-05 13:18:03 | announced | |
Publication List
Gebru NT, Guergues J, Verdina LA, Wohlfahrt J, Wang S, Armendariz DS, Gray M, Beaulieu-Abdelahad D, Stevens SM, Gulick D, Blair LJ, Fkbp5 gene deletion: Circadian rhythm profile and brain proteomics in aged mice. Aging Cell, ():e14314(2024) [pubmed] |
10.1111/acel.14314; |
Keyword List
submitter keyword: knock out, brain, hippocampus, DIA, KO, PRM, aged, amygdala, mouse,Fkbp5 |
Contact List
Stanley Stevens |
contact affiliation | University of South Florida, USA |
contact email | smstevens@usf.edu |
lab head | |
Stanley Stevens |
contact affiliation | University of South Florida |
contact email | smstevens@usf.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD049439 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD049439
- Label: PRIDE project
- Name: Fkbp5 Gene Deletion: Impacts on Circadian Rhythmicity and Brain Proteomics in Aged Mice