PXD049341 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Function of CK2 selectively affects the endoplasmic reticulum and the Golgi apparatus in mTOR-mediated autophagy induction. |
Description | Selective autophagy of the endoplasmic reticulum, known as ER-phagy, is essential to maintain ER homeostasis. We recently showed that members of the autophagy receptor family FAM134 are regulated by phosphorylation-dependent ubiquitination. In an unbiased screen we had identified several kinases downstream of mTOR with profound impact on ER-phagy flux, upon them ATR and CK2. Inhibition of CK2 by SGC-CK2-1 prevented regulatory ubiquitination of FAM134B and FAM134C upon autophagy activation as well as the formation of high-density FAM134B- and FAM134C-clusters. Here we report on additional resource data of global proteomics upon CK2 and ATR inhibition, respectively. Our data suggests that the function of CK2 is mainly limited to the ER / ER-phagy and Golgi, while ATR inhibition by VE-822 affects the vast majority of organelles / selective autophagy pathways. |
HostingRepository | PRIDE |
AnnounceDate | 2025-03-07 |
AnnouncementXML | Submission_2025-03-07_03:11:49.264.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Pablo Sanz Martinez |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-02-12 09:51:12 | ID requested | |
⏵ 1 | 2025-03-07 03:11:50 | announced | |
Publication List
10.1080/15548627.2024.2395725; |
Sanz-Martinez P, Berkane R, Stolz A, Function of CSNK2/CK2 selectively affects the endoplasmic reticulum and the Golgi apparatus in mtor-mediated autophagy induction. Autophagy, 21(2):480-486(2025) [pubmed] |
Keyword List
submitter keyword: Human, Multiplexed, LC-MS,TMTpro 18plex,GPRC,Compounds |
Contact List
Alexandra Stolz |
contact affiliation | Goethe University, Institute for Biochemistry II, Frankfurt am Main |
contact email | stolz@em.uni-frankfurt.de |
lab head | |
Pablo Sanz Martinez |
contact affiliation | PhD student |
contact email | P.SanzMartinez@med.uni-frankfurt.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD049341
- Label: PRIDE project
- Name: Function of CK2 selectively affects the endoplasmic reticulum and the Golgi apparatus in mTOR-mediated autophagy induction.