PXD049331-1

PXD049331 is an original dataset announced via ProteomeXchange.

Title	Mule milk as an alternative to donkey milk for the nutrition of allergic infants
Description	Cow milk is a widespread food, but several children are allergic to it – chiefly because of adverse reactions to its proteins. Nutritionally valid, hypoallergenic surrogates are highly sought after, and among them donkey milk is prized for its tolerability and human-like composition. Still, donkeys produce very little milk, with disastrous consequences for marketability and supply chain. Mules are crosses between a donkey stallion and a horse mare, and female ones can be set pregnant via embryo transfer for later lactation, conceivably within economically sustainable production strategies. Owing to their bigger average body size, mules should produce more milk than donkeys, yet the protein profile and allergenicity of mule milk are vastly unknown. Here we present a proteomics characterization of mule milk, obtained via a mule-in-mule surrogate gestation. Through experiments on blood sera from allergic children, we show that such milk is less allergenic than its cattle analog, possibly being at some advantage even with respect to donkey milk.
HostingRepository	PRIDE
AnnounceDate	2026-07-16
AnnouncementXML	Submission_2026-07-16_01:52:36.554.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martina Bartolucci
SpeciesList	scientific name: Equus caballus (Horse); NCBI TaxID: NEWT:9796; scientific name: Equus asinus asinus; NCBI TaxID: NEWT:83772;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-12 06:05:01	ID requested
⏵ 1	2026-07-16 01:52:37	announced

10.1016/J.HELIYON.2025.E43483;

submitter keyword: mule, proteomics, mule-in-mule, milk, allergy

Andrea Petretto
contact affiliation	IRCCS Istituto G Gaslini
contact email	a.petretto@gmail.com
lab head
Martina Bartolucci
contact affiliation	IRCCS Gaslini
contact email	smartibartolucci@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD049331
     1. Label: PRIDE project
     2. Name: Mule milk as an alternative to donkey milk for the nutrition of allergic infants