PXD049226-2
PXD049226 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Characterization of lysine acetylome in mice subjected to chronic intermittent hypoxia |
| Description | Chronic intermittent hypoxia (CIH) can negatively affect hippocampal function through various molecular mechanisms. Protein acetylation, a frequently occurring modification, plays crucial roles in synaptic plasticity and cognitive processes. However, the global protein acetylation induced by CIH in the hippocampus and its specific effects on hippocampal function and behaviour remain poorly understood. In this study, we employed Liquid chromatography-tandem mass spectrometry to examine the lysine acetylome of the hippocampus in healthy adult mice exposed to intermittent hypoxia for 4 weeks (as a CIH model) and in normoxia mice (as a control). We identified and quantified 2184 lysine acetylation sites in 1007 proteins. CIH differentially regulated 280 acetylated sites on 213 proteins, with 35.21% of acetylated proteins annotated in mitochondria. Analysis of these acetylated proteins revealed disturbances primarily in oxidative phosphorylation, the tricarboxylic acid (TCA) cycle, and glycolysis, all of which are localized exclusively to mitochondria. |
| HostingRepository | iProX |
| AnnounceDate | 2024-02-07 |
| AnnouncementXML | Submission_2024-03-11_01:15:20.824.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Fan Liu |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | acetylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-02-07 00:36:25 | ID requested | |
| 1 | 2024-02-14 01:34:54 | announced | |
| ⏵ 2 | 2024-03-11 01:15:22 | announced | 2024-03-11: Update information. |
Publication List
| Liu F, Yan W, Chen C, Zeng Y, Kong Y, He X, Pei P, Wang S, Zhang T, Acetylome analyses provide novel insights into the effects of chronic intermittent hypoxia on hippocampus-dependent cognitive impairment. Front Mol Neurosci, 17():1324458(2024) [pubmed] |
Keyword List
| submitter keyword: Lysine acetylome, chronic intermittent hypoxia, hippocampus |
Contact List
| Shan Wang | |
|---|---|
| contact affiliation | Children's Hospital Capital Institute of Pediatrics |
| contact email | 598557219@qq.com |
| lab head | |
| Fan Liu | |
| contact affiliation | Children's Hospital Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. |
| contact email | liufan5023@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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