PXD049214-1

PXD049214 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	HDX-MS of murine urokinase plasminogen activator and variants
Description	HDX-MS data revealing long-range allostery that affects the catalytic activity of the serine protease, murine urokinase plasminogen activator. The allostery is mediated by the disordered region connecting the N-terminal EGF and kringle domains to the protease domain.
HostingRepository	MassIVE
AnnounceDate	2024-03-29
AnnouncementXML	Submission_2024-03-29_12:50:09.638.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Elizabeth Komives
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt G2-S HDMS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-06 13:21:53	ID requested
⏵ 1	2024-03-29 12:50:10	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: allostery, protease, plasminogen activator, intrinsically disordered region

submitter keyword: allostery, protease, plasminogen activator, intrinsically disordered region

Contact List

Elizabeth Komives
contact affiliation	UCSD
contact email	ekomives@ucsd.edu
lab head
Elizabeth Komives
contact affiliation	UCSD
contact email	ekomives@ucsd.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000094027/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000094027/