PXD049183 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomics of BACE2 inhibition on patient-derived EWS cells |
| Description | Ewing sarcoma (EWS), a highly aggressive cancer with limited treatment options and low survival rates. Transcriptomics revealed β-Secretase 2 (BACE2) presence while BACE2 inhibition attenuated EWS cell growth, abolished tumor-initiating capacity, and altered cell cycle/metastatic signatures. To further understand the mechanism of BACE2 inhibition in EWS, we performed a global proteomic analysis of BACE2-treated vs untreated EWS cells. The proteomic dataset revealed interference at various cellular levels following BACE2 inhibition, most of which was compatible with our findings in pPDX transcriptomics and in EWS cell-based assays, including modulation of the cell cycle, metastatic signature and PI3K/Akt-related pathways. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-03 |
| AnnouncementXML | Submission_2026-09-03_06:27:03.770.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tamar Geiger |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-02-05 07:55:56 | ID requested | |
| ⏵ 1 | 2026-09-03 06:27:04 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: proteomics, LC-MS, BACE2,Ewing Sarcoma, inhibition, cell line |
Contact List
| Prof. Tamar Geiger |
|---|
| contact affiliation | Cancer proteomics lab Department of Molecular Cell Biology Weizmann Institute of science, Rehovot, Israel |
| contact email | tami.geiger@weizmann.ac.il |
| lab head | |
| Tamar Geiger |
|---|
| contact affiliation | Weizmann Institute of Science |
| contact email | geiger@tauex.tau.ac.il |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD049183 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD049183
- Label: PRIDE project
- Name: Proteomics of BACE2 inhibition on patient-derived EWS cells
