PXD049103-1

PXD049103 is an original dataset announced via ProteomeXchange.

Title	The protein phosphorylation in HCT116 cells with or without the over-expressed LRRC8A
Description	It’s hypothesized that LRRC8A may regulate cell proliferation and migration by participating in the transduction of cell signaling. Then protein phosphorylation in cells with or without the over-expressed LRRC8A was detected and quantified by mass spectroscopy. A total of 564 proteins and 1,102 phosphorylated sites were identified, of which 342 proteins and 538 phosphorylated sites were successfully quantified. A total of 32 downregulated and 68 upregulated proteins were noted in the OE-LRRC8A group compared with the LV-ctrl group; the intensities of 79 phosphorylated sites in 62 proteins were considerably altered by the overexpression of the LRRC8A protein; all the differential sites included 41 downregulated sites and 38 upregulated sites.
HostingRepository	iProX
AnnounceDate	2024-02-01
AnnouncementXML	Submission_2024-03-31_20:11:17.906.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Haifeng Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-01 21:22:19	ID requested
⏵ 1	2024-03-31 20:11:18	announced

Dataset with its publication pending

submitter keyword: LRRC8A, protein phosphorylation, HCT116 cell

Haifeng Zhang
contact affiliation	Xi'an Jiaotong University
contact email	zhf19841011@xjtu.edu.cn
lab head
Haifeng Zhang
contact affiliation	Xi'an Jiaotong University
contact email	zhf19841011@xjtu.edu.cn
dataset submitter

iProX dataset URI