PXD048962-1

PXD048962 is an original dataset announced via ProteomeXchange.

Title	Serum-derived exosome proteomics unveils the distinct and adjustable of the dampness constitution in traditional Chinese medicine
Description	Currently, there are no established objective and sensitive diagnostic methods in traditional Chinese medicine (TCM) to differentiate dampness constitution (DC), which is often caused by prolonged exposure to an improper diet or a humid environment. These factors trigger chronic, immune and metabolic diseases, posing a significant threat to human health. In this study, we obtained high-quality serum exosome proteins and conducted proteome profiling across two cohorts. Cohort 1 included 20 healthy subjects, with a balanced constitution (BC, n = 10) and DC (n = 10), to characterize the protein basis of DC. Cohort 2 comprised a clinical randomized controlled trial investigating the treatment of dampness-related hyperlipidemia (DC-hyperlipidemia) using Fuling Zexie decoction (FLZXD). By comparing this cohort with the BC group, the study assessed the efficacy of FLZXD in treating DC-hyperlipidemia. The active components of FLZXD, identified through extensive patent experiments and pharmacological evidence, including Fuling, Zexie, and Baizhu. We successfully identified and validated four targets related to the diagnosis and treatment of DC-hyperlipidemia. This study confirms that DC is distinguishable through serum-derived exosome proteomics and can be reversed through herbal treatment. This diversification strategy has validated our characterization of the DC, offering a paradigm for research in TCM constitution with significant clinical implications.
HostingRepository	iProX
AnnounceDate	2024-11-01
AnnouncementXML	Submission_2024-11-01_01:05:56.412.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yao Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion; Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-29 00:21:16	ID requested
⏵ 1	2024-11-01 01:05:56	announced

Dataset with its publication pending

submitter keyword: dampness, Fuling Zexie decoction, traditional Chinese medicine, hyperlipidemia, patent, network pharmacology

Ping Xu
contact affiliation	Beijing Proteome Research Center
contact email	xuping_bprc@126.com
lab head
Yao Zhang
contact affiliation	Beijing Proteome Research Center
contact email	zhangyaowsw@163.com
dataset submitter

iProX dataset URI