PXD048923-1

PXD048923 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic mapping of fibroblasts from patients with HSP60 deficiency
Description	Deficiency of the mitochondrial chaperone HSP60 has detrimental effects on the mitochondrial functions, and can in patient’s lead to hypomyelination disorder. The present study investigates the proteome in cultivated skin fibroblasts originating from two patients with HSP60 genetic variants and hypomyelination.
HostingRepository	PRIDE
AnnounceDate	2025-09-11
AnnouncementXML	Submission_2025-09-11_01:00:34.475.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD048923
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Johan Palmfeldt
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-26 10:32:09	ID requested
⏵ 1	2025-09-11 01:00:35	announced

Publication List

10.1016/j.molmet.2024.102009;
C, ö, mert C, Kj, æ, r-S, ø, rensen K, Hansen J, Carlsen J, Just J, Meaney BF, Ø, stergaard E, Luo Y, Oxvig C, Schmidt-Laursen L, Palmfeldt J, Fernandez-Guerra P, Bross P, HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis. Mol Metab, 88():102009(2024) [pubmed]
10.6019/PXD048923;

10.1016/j.molmet.2024.102009;

C, ö, mert C, Kj, æ, r-S, ø, rensen K, Hansen J, Carlsen J, Just J, Meaney BF, Ø, stergaard E, Luo Y, Oxvig C, Schmidt-Laursen L, Palmfeldt J, Fernandez-Guerra P, Bross P, HSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis. Mol Metab, 88():102009(2024) [pubmed]

10.6019/PXD048923;

Keyword List

submitter keyword: HSP60, LC-MS, mitochondria, fibroblast

submitter keyword: HSP60, LC-MS, mitochondria, fibroblast

Contact List

Johan Palmfeldt
contact affiliation	Aarhus University, Denmark
contact email	johan.palmfeldt@clin.au.dk
lab head
Johan Palmfeldt
contact affiliation	Aarhus University Hospital
contact email	johan.palmfeldt@clin.au.dk
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD048923

PRIDE project URI

Repository Record List

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