PXD048895-1

PXD048895 is an original dataset announced via ProteomeXchange.

Title	Sex Differences in Response to Glutathione Precursors in the Aging Heart
Description	Diastolic dysfunction in the aged population is multifactorial. Common features of the aging heart are dysregulated metabolism, elevated oxidative stress, inflammation and fibrosis, where each of these conditions can linked together and further promote the altered phenotype. It becomes increasingly apparent that aged male and female hearts are phenotypically different and these basic differences dictate their responses to treatments such as a response to antioxidants. We used Glycine and N-Acetyl-Cysteine (GlyNAC, precursors of glutathione)- supplemented diet to monitor its effect on cardiac function and exercise performance. We found that this pharmacological intervention was beneficial for male but not female aged mice and the small but significant changes were observed not only on cardiac functions but also on molecular levels where fatty acid metabolism was improved and cardiac matrix stiffness was reduced.
HostingRepository	PRIDE
AnnounceDate	2024-11-06
AnnouncementXML	Submission_2024-11-05_16:08:54.709.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexander Saltzman
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue
Instrument	Orbitrap Eclipse; Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-25 13:23:46	ID requested
⏵ 1	2024-11-05 16:08:55	announced

10.1093/gerona/glae258;

Angelini A, Garcia Marquez G, Malovannaya A, Fiorotto ML, Saltzman A, Jain A, Trial J, Taffet GE, Cieslik KA, Sex Differences in Response to Diet Enriched With Glutathione Precursors in the Aging Heart. J Gerontol A Biol Sci Med Sci, 80(2):(2025) [pubmed]

submitter keyword: heart, sex differences, mitochondria,aging, extracellular matrix

Katarzyna Cieslik
contact affiliation	Baylor College of Medicine
contact email	cieslik@bcm.edu
lab head
Alexander Saltzman
contact affiliation	Baylor College of Medicine
contact email	saltzman@bcm.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD048895
     1. Label: PRIDE project
     2. Name: Sex Differences in Response to Glutathione Precursors in the Aging Heart